![]() ![]() J Neural Transm (Vienna) 123:431–438īorroni B, Turla M, Bertasi V, Agosti C, Gilberti N, Padovani A (2008) Cognitive and behavioral assessment in the early stages of neurodegenerative extrapyramidal syndromes. J Neurol Neurosurg Psychiatry 77:454–456īiundo R, Weis L, Bostantjopoulou S, Stefanova E, Falup-Pecurariu C, Kramberger MG, Geurtsen GJ, Antonini A, Weintraub D, Aarsland D (2016) MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study. J Neurol Neurosurg Psychiatry 76:420–422īak TH, Caine D, Hearn VC, Hodges JR (2006) Visuospatial functions in atypical parkinsonian syndromes. Neurocase 11:268–273īak TH, Rogers TT, Crawford LM, Hearn VC, Mathuranath PS, Hodges JR (2005b) Cognitive bedside assessment in atypical parkinsonian syndromes. Parkinsonism Relat Disord 21:1273–1277īak TH, Crawford LM, Hearn VC, Mathuranath PS, Hodges JR (2005a) Subcortical dementia revisited: similarities and differences in cognitive function between progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). J Neurol Neurosurg Psychiatry 74:1215–1220Īuzou N, Dujardin K, Biundo R, Foubert-Samier A, Barth C, Duval F, Tison F, Defebvre L, Antonini A, Meissner WG (2015) Diagnosing dementia in multiple system atrophy by applying Movement Disorder Society diagnostic criteria for Parkinson’s disease dementia. Overall, MoCA is more sensitive than MMSE in detecting cognitive impairment in atypical parkinsonism and together with verbal fluency would be a useful test to support PSP diagnosis.Īarsland D, Litvan I, Salmon D, Galasko D, Wentzel-Larsen T, Larsen JP (2003) Performance on the dementia rating scale in Parkinson’s disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer’s disease. These preliminary results suggest that PSP and MSA, similar to PD patients, may present normal MMSE and reduced MoCA performance. ![]() By contrast, MMSE presented an overall ceiling effect for most subitems, except for the pentagon scores, where PSP did less well than MSA or PD patients. MSA: 71 % specificity, 70 % sensitivity). PD: 86 % specificity, 70 % sensitivity PSP vs. More specifically, a cut-off score of 7 F-words or less per minute would support a diagnosis of PSP (PSP vs. MoCA total score as well as its letter fluency subitem differentiated PSP from MSA and PD with high specificity and moderate sensitivity. The mean MMSE was higher than the mean MoCA score in each MSA (27.7 ± 2.4 vs. ![]() Receiver-operating characteristic (ROC) curves were calculated. We assessed between-group differences for MMSE, MoCA, and their subitems. In this multicenter observational study, MMSE and MoCA were administered in a random order to 130 patients: 35 MSA, 30 PSP and 65 age, and education and gender matched-PD. To determine if Montreal Cognitive Assessment (MoCA) is more sensitive than the commonly used Mini-Mental State Examination (MMSE) in detecting cognitive abnormalities in patients with probable progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) compared with Parkinson’s disease (PD).
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